Tag Archives: Cancer
University of Applied Sciences Utrecht and QVQ established collaboration on llama antibody technology

University of Applied Sciences Utrecht (HU) has excellent facilities for studies on Chemical Technology and Life Sciences and these facilities can be used by industry. QVQ has a number of very interesting subjects for students of HU in the area of llama antibody technology. In 2015 a student of HU (Marjolein Kuijpers) worked at QVQ and […]

Rapid optical imaging of human breast tumour xenografts using anti Her2 VHH

Abstract PURPOSE: Molecular optical imaging using monoclonal antibodies is slow with low tumour to background ratio. We used anti-HER2 VHHs conjugated to IRDye 800CW to investigate their potential as probes for rapid optical molecular imaging of HER2-positive tumours by the determination of tumour accumulation and tumour to background levels. METHODS: Three anti-HER2 VHHs (11A4, 18C3, […]

Anti adhesive VHH targeting the integrin alpha 3 beta 1 (VLA-3)

Abstract Therapeutic approaches aimed at targeting tumor surface markers using monoclonal antibodies provide a powerful strategy in cancer treatment. Here we report selection of single variable domains (VHH) of llama heavy chain antibodies, using a VHH-phage-display library. A reverse proteomic approach was used to identify the cognate proteins recognized by enriched VHH on HeLa cells. […]

Targeting using internalizing nanobody-decorated nanoparticles

Abstract The hepatocyte growth factor receptor (HGFR, c-Met or Met) is a receptor tyrosine kinase that is involved in embryogenesis, tissue regeneration and wound healing. Abnormal activation of this proto-oncogene product is implicated in the development, progression and metastasis of many cancers. Current therapies directed against Met, such as ligand- or, dimerization-blocking antibodies or kinase […]