Career

Join us at QVQ

For almost a decade, we have worked on the cutting edge of modern bio-research. We push our boundaries on a daily basis and work on new and innovative ways to find answers to health care questions all over the world.

If you’re interested in joining the QVQ team as a student or colleague, please contact us via career@qvquality.com.

 

Current vacancies:

*** Senior technician/Projectleader

*** Early Stage Researcher position in the ONCORNET 2.0 ITN

*** Open application

 

Senior technician/Projectleader

QVQ Holding B.V. is looking for a new colleague to reinforce its young team of enthusiastic researchers.

QVQ is SME specialized in the development of VHH, i.e. single domain antibody fragments derived from heavy chain-only antibodies found in members of the camelidae family (e.g. camel, llama, alpaca). We develop lead panels of VHH molecules as a service for both academic and industrial customers. In this process, we focus on the demands of the customer and aim for high quality deliverables. Besides these CRO activities, QVQ provides an expanding portfolio of VHH molecules as purified and labeled protein for the detection and molecular imaging of age-related diseases, inflammatory disorders and cancer.

We are looking for a senior technician/project manager with a BASc/HLO or MSc degree with preferably a few years of relevant work experience in the antibody field and an industrial environment. The ideal candidate is broadly interested with respect to both technical and scientifical topics and has excellent technical, social, communicative and motivational skills. Expertise in antibody technologies like phage display, antibody production, affinity purification and ELISA is preferred, as well as proven experience in molecular biological techniques like cloning, DNA and protein electrophoresis.

This position provides the opportunity to work/discuss with customers from leading academic centers, renowned research institutes and both small and large industry. As a (future) project manager, you will supervise complete CRO- and research projects from startup phase up to the delivery of quality-controlled lead molecules. This team effort will involve lab activities, communication (both with the customers and the rest of the QVQ team), planning, adherence to deadlines and reporting.

If you’re interested in this position or would like to know more, please contact us via career@qvquality.com.

 

Early Stage Researcher position in the ONCORNET 2.0 ITN

For the European Training Network project ONCORNET2.0 QVQ is looking for a highly motivated and talented student with a MSc degree who are interested in an ambitious multidisciplinary project on oncogenic G protein-coupled receptors (GPCRs).

ONCORNET2.0 will bring together the leading research scientists and labs in Europe with an interest in GPCRs and 15 early stage researchers. Together, we will employ all the latest multidisciplinary research technologies to understand the role of these GPCRs in cancer and develop CXCR4 and CXCR7 tools for diagnostic and therapeutic purposes. Importantly, developed approaches can be extrapolated to other oncogenic GPCRs. The ONCORNET consortium will offer an extensive multidisciplinary training programme to the ESRs to ensure that they can operate in today’s drug discovery programmes. This will include both research (e.g. drug discovery, proteomics, imaging, modelling) and transferable (e.g. entrepreneurship, writing, media training) skill sets –that is rarely offered at PhD level. We will train ESRs to develop the next generation of multidisciplinary scientists with skills that are highly demanded by many of today’s employers in drug development industries. More information on ONCORNET2.0 can be found on: http://www.oncornet.eu/index.php/about-us

QVQ will host early stage researcher 2 (ESR2) and supervise the project entitled: Nanobodies as modulators of CXCR4/ACKR3/RTK function.

Aims:

  1. The development and characterization of multivalent anti-CXCR4/ACKR3/RTK nanobody constructs to modulate CXCR4/ACKR3 oligomers.
  2. Use multivalent Nbs for imaging of CXCR4/ACKR3 using site-directionally conjugated nanobodies

Methodology:

Nanobody constructs will be generated through genetic fusion, cloning and production in E.coli or S.cerevisiae. Produced nanobody constructs will be purified using affinity chromatography and gel filtration. Generated molecules will be assessed for production yields, integrity and functionality/potency in close collaboration with the VU University Amsterdam and University of Nottingham. This will involve a wide range of established techniques (UV-VIS spectrometry, SDS-PAGE, ELISA, ligand displacement and reporter gene assays and bioluminescence resonance energy transfer (BRET)). In addition, generated nanobody constructs will be turned into imaging agents via directional conjugation, which will be tested for imaging receptor complexes by using modalities.

Planned secondments:

Vrije Universiteit Amsterdam (Smit lab)

University of Nottingham (Hill lab)

 

Required diploma: MSc in biology, chemistry, biochemistry, microbiology or molecular-, biomedical-, pharmaceutical- or related life sciences.

Required expertise: biochemistry and molecular biology (DNA and protein level).

Recommended expertise: molecular cloning, phage-display, protein production and purification, affinity chromatography, FPLC, (yeast) fermentation, site-directed conjugations, SDS-PAGE, ELISA, FACS, cell culture, cell based assays, fluorescence microscopy and working experience in industry.

Application procedure: http://www.oncornet.eu/index.php/recruitment

Please send the following information (as one pdf file) to the email address for that given ESR position* including:

  Detailed CV (include information on your BSc and MSc studies, languages, achievements, expertise)

  Motivation letter, addressed to the ONCORNET2.0 selection committee, explaining your motivation why you apply with us. You have to indicate which ONCORNET ESR projects you are interested in (please motivate your selection).

  Provide contact details of at least 2 references (names, addresses, emails).

  Reference letter from one of the enlisted references

  Copies of your key educational certificates

  Transcript of Records (i.e. documents enlisting your performance as BSc and MSc student over time by listing the course units or modules taken, credits gained and the grades awarded). If you have not completed your MSc degree yet include all grades obtained so far.

If applicable provide a language certificate.

Email for application: career@qvquality.com

 

Timelines:

Deadline application – January 1, 2020

Selection/Skype interviews – January, 2020

General interview day in Amsterdam – February 11, 2020