Many diseases have genetic and physiological components. For historic reasons QVQ Holding has selected VHH against a restricted number of neuromuscular diseases and VHH that can be used in Tissue Repair.
QVQ also developed a small set of VHH directed against markers involved in the relieve of protein toxicity effect, such as Clusterin, HSP70, GC globulin.
Moreover QVQ has VHH directed against few actors involved in processing of amyloid plasma protein (APP), which leads to the formation of the pathogenic Aβ peptide, responsible for Alzheimer disease (AD).
We also work in the field of Cardiovascular Diseases.
Ageing of the population results in a number of age related diseases. Osteoarthritis/Osteoporoses, Invertebral Disk Disease and Renal fibroses are prominent age related diseases with hundreds of millions patients all over the world, in particular in the developed countries. Often the cure of these diseases is collectively called Tissue Repair. Tissue Repair is also required to heal wounds.
There are a large number of neuromuscular diseases and together with Leiden University Medical Center, UU and later on QVQ have done work in various areas within neuromuscular diseases. An extensive program on OPMD has delivered proof that VHH can be used as intrabodies to prevent aggregation of unwanted proteins which can lead to muscular diseases. This knowledge has been used in other programs for Alzheimer’s disease and Huntington, among others.
Atherosclerosis-related cardiovascular events are prevalent in developed countries and usually fatal. Cardiovascular diseases are the leading cause of death globally with about 15 million death in 2015. In spite of this dramatic figure it is also the disease that for a considerable part can be prevented or at least its onset can be retarded by adopting a healthy life style. The first manifestation of such event is usually cardiac arrest or stroke. It is therefore very important to distinguish between the stable and non-stable plaque at an early stage, in order to direct beneficial interventions for the patient.